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与恩特卡维尔启动相关的一种罕见的神经病变病例
Courtney Overton1, Logan Brock2, Bindu Betapudi3
1Department of Pharmacy, University of Tennessee Medical Center, Knoxville, TN, USA.
概括
恩特卡维尔是治疗慢性乙型肝炎病毒 (CHB) 感染的药物,很少会导致肌肉病变. 一名患有CHB的患者在开始服用恩特卡维尔后出现肌肉衰弱,在转换为特诺福维尔二松醇烟酸后,这种情况得到缓解.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 药理学 药理学是指药理学的学科.
背景情况:
- 乙型肝炎病毒 (HBV) 感染对健康构成重大风险,包括肝硬化和肝细胞癌.
- 恩特卡维尔是慢性乙型肝炎病毒 (CHB) 感染的推治疗方法.
- 肌肉病是因特卡维尔治疗的罕见副作用.
研究的目的:
- 在患有CHB的患者中报告疑似因特卡维尔相关肌肉病变的病例.
- 突出恩特卡维尔可能产生的罕见但严重的不良反应.
- 强调监测安特卡维尔治疗的患者的重要性.
主要方法:
- 一个65岁的女性患者的病例报告,她有多种并发病史和CHB.
- 在开始安特卡维尔后,对症状发展的临床观察.
- 评估患者对停用安特卡维尔药物的反应,并转换为特诺福维尔二二醇烟酸.
主要成果:
- 患者在开始服用恩特卡维尔后不久就出现了显著的疲劳和肌肉虚弱.
- 这些症状发生在没有急性肝衰竭的情况下.
- 暂停安特卡维尔治疗并开始服用特诺福维尔二二醇烟酸,导致症状改善.
结论:
- 与恩特卡维尔相关的肌肉病变是一种罕见但严重的不良事件,可能发生在CHB患者中.
- 在接受恩特卡维尔的患者中,对肌肉病的警监测至关重要.
- 对于出现不良反应的患者,应考虑使用替代抗病毒疗法,如tenofovir disoproxil fumarate.
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