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案例报告:罕见的杜比卢马布相关的肺结核和肺外结核
1Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou, Zhejiang, People's Republic of China.
Infection and drug resistance
|October 8, 2025
概括
对亚托皮性皮炎的杜皮卢马布治疗可能会增加结核病的风险. 这份病例报告强调了在杜皮卢马布治疗后发展的肺结核和肺外结核,敦促临床警.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 传染性疾病 传染性疾病
背景情况:
- 杜皮卢马布是一种单克隆抗体,向IL-4Rα,有效治疗中度至重度的亚托皮性皮炎 (AD).
- 杜皮卢马布对IL-4和IL-13信号的抑制会影响免疫反应.
研究的目的:
- 报告患有肺结核 (PTB) 和肺外结核 (EPTB) 的病例,该病例发生在用dupilumab治疗的患者身上.
- 为了提高人们对杜皮卢马布治疗期间可能发生的肺结核再激活或发展的认识.
主要方法:
- 一个71岁的男性患者的病例报告,他有AD病史.
- 在dupilumab治疗后对PTB和EPTB的临床观察和诊断.
主要成果:
- 患者在启动dupilumab治疗后发展出PTB和EPTB.
- 连接dupilumab与结核病恶化的确切机制正在调查中,但可能涉及抑制的炎症基因表达和巨细胞功能.
结论:
- 这是第一次报告与dupilumab相关的PTB和EPTB病例.
- 临床医生应在接受dupilumab治疗的患者中保持对结核病的高度警,特别是在结核病流行地区.
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