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Updated: Jan 6, 2026

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
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在一种新型的LDLR变异的法不耐受性FH患者中PCSK9抑制剂失效:一个病例报告

Yuan Li1, Huiyan Jiang1, Yajuan Xiong1

  • 1Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.

Frontiers in cardiovascular medicine
|October 8, 2025
PubMed
概括

对PCSK9抑制剂耐药的家族高胆固醇血症 (FH) 患者可能具有新型的LDLR基因变异. 基因检测可以为这些具有挑战性的病例提供个性化的治疗指南.

关键词:
这是一种PCSK9抑制剂.案例报告案例报告家庭性高胆固醇血症是什么?基因突变是一种基因突变.低密度脂蛋白受体 (LDLR) 是一种低密度脂蛋白受体.类他类药物不耐受性

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