为控制先天和自适应性免疫反应而设计的多糖类
Jutaek Nam1,2, April Kim3,4,2, Kidong Kim5,2
1College of Pharmacy, Chonnam National University, Gwangju, South Korea.
Nature reviews bioengineering
|October 8, 2025
概括
微生物多糖类作为病原体相关的分子模式 (PAMPs),刺激免疫细胞. 这些化合物通过调节T细胞反应,为开发新型疫苗和免疫疗法提供了多功能平台.
科学领域:
- 免疫学 免疫学 免疫学
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- 特定的T细胞激活对于疫苗和免疫疗法至关重要,但仍然具有挑战性.
- 微生物多糖是强大的免疫调节剂,与病原体识别受体 (PRR) 相互作用.
- 这些相互作用会触发强大的免疫反应,调节T细胞功能并激活免疫通路.
研究的目的:
- 审查多糖类作为PRRs认可的PAMP的作用.
- 探索多糖的免疫调节潜力,用于生物医学应用.
- 研究聚糖在疫苗,免疫辅助剂,免疫调节和药物输送中的工程方面和应用.
主要方法:
- 对多糖,PRR和免疫反应的现有文献的综述.
- 对生物医学应用的多糖体工程原理的分析.
- 探索多糖诱导的训练免疫力.
主要成果:
- 多糖类作为PAMP起作用,通过PRRs激活树突细胞和巨细胞.
- 它们表现出免疫激活和免疫调节功能,影响T细胞反应.
- 多糖类可以诱导训练免疫力,增强对病原体的反应能力.
结论:
- 多糖是有前途的免疫调节剂,具有多种生物医学应用.
- 聚糖的材料工程可以导致有效的疫苗和免疫疗法.
- 这些化合物具有治疗自身免疫性疾病和其他疾病的潜力.
相关概念视频
Cell-mediated Immune Responses
83.2K
Overview
83.2K
Antigens Involved in Adaptive Immunity
1.2K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
1.2K
Introduction to Innate and Adaptive Immunity
8.4K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
8.4K
What is the Immune System?
126.1K
Overview
126.1K
Immune Response Against Viral Pathogens
1.6K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.6K
Biosynthesis of Polysaccharides
510
Polysaccharides such as glycogen and starch are synthesized from nucleoside diphosphate sugars, primarily uridine diphosphate glucose (UDPG) and adenosine diphosphate glucose (ADPG). These activated glucose donors act as key intermediates in carbohydrate metabolism and biosynthesis. UDPG primarily involves glycogen synthesis in animals and many bacteria, while ADPG plays a fundamental role in starch synthesis in plants and certain bacteria.UDPG is formed when glucose-1-phosphate reacts with...
510


