血压 姿势变化 变化与较低的认知有关:S.AGES队列
Mathilde Strumia1,2, Jean-Sébastien Vidal3,4, Philippe Cestac1,2
1Maintain Aging Research team, CERPOP Université de Toulouse, Inserm, Université Paul Sabatier Toulouse France.
Journal of the American Heart Association
|October 8, 2025
概括
高血压 (BP) 姿势变化的变化与老年人的认知功能下降有关. 这一发现表明,管理血压不稳定可能对大脑健康很重要.
科学领域:
- 老年学是一门学科.
- 心血管健康 心血管健康
- 神经科学是一个神经科学.
背景情况:
- 血压 (BP) 变化和姿势变化与认知能力下降有关.
- 之前的研究表明,随着心血压 (SBP) 的姿势变化变化,痴呆风险更高.
- 在社区居住的老年人中,BP姿势变化可变性和认知功能之间的关联需要进一步调查.
研究的目的:
- 调查BP姿势变化可变性和社区老年人的认知功能之间的关联.
- 分析访问到访问BP姿势变化变化和认知表现之间的关系.
主要方法:
- 利用了来自S.AGES队列的数据,包括2974名参与者 (平均年龄78岁) 超过3年.
- 计算6个月间的静态SBP和透气BP比率,以评估每次访问的BP姿势变化的变化.
- 采用线性混合模型来分析每年通过迷你精神状态检查评估的血压变化指标和认知功能之间的关联.
主要成果:
- 访问到访问的SBP姿势变化的变化与较低的认知功能有显著的关联 (调整后β=-0.15,P=0.01).
- 观察到类似的关联是访问到访问的透静血压BP姿势变化的变化.
- 这些发现在调整人口统计,心血管风险因素,坐着的血压和降血压治疗后仍然具有意义.
结论:
- 在SBP和腹痛BP两种姿势变化中,访问到访问的变化与认知功能的降低有关.
- 需要进一步的研究来确定管理静态血压不稳定的方法是否可以帮助老年人保持认知功能.
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