一个跨性别和性别多样化的多中心群体,多发性硬化症患者
Alexandra Balshi1, Talia B Feldman2,3, John P Dempsey1
1Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
概括
变性人和患有多发性硬化症 (MS) 的性别多样的人在性别肯定激素治疗 (GAHT) 上通常会经历轻微的疾病. 在这项研究中,丸激素治疗没有对MS活动或残疾产生负面影响.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 了解跨性别和性别多样性 (TGD) 个体的多发性硬化症 (MS) 结果对于改善他们的临床护理至关重要.
- 调查性别肯定激素治疗 (GAHT) 对TGD患者MS (PwMS) 的MS的影响是必不可少的.
研究的目的:
- 为了描述TGD PwMS的一组.
- 评估在GAHT开始后MS疾病活动和结果的变化.
- 确定影响该人口的临床管理和社会健康驱动因素 (SDoH) 中的潜在差距.
主要方法:
- 进行了多中心对医疗记录的回顾性审查.
- 收集的数据包括TGD PwMS的人口统计,性别认同和临床信息.
- 分析重点关注与GAHT相关的MS疾病活动和结果.
主要成果:
- 确定了22个TGD PwMS,其中21个在出生时被分配为女性 (AFAB).
- 该队列表现出轻微的MS残疾 (EDSS中位数1.5) 没有需要门诊辅助.
- 的GAHT与复发增加,残疾进展,步行速度减慢或在成像上出现新的MS病变无关.
结论:
- 一个受过良好教育,拥有良好保险的TGD PwMS队列,主要是AFAB和高效疾病修饰疗法 (DMT),经历了轻度MS.
- 这些发现为TGD个体的MS疾病轨迹提供了保证.
- 在这个TGD PwMS队列中,没有发现外源的安全问题.
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