时间分辨率的汗水收集用于体外SERS分析:弥合可穿戴性和敏感性
Yisong Yu1, Xiaohui Fang1, Zhenle Qin1
1School of Physics and Optoelectronic Engineering, Beijing University of Technology, Beijing 100124, China.
ACS sensors
|October 8, 2025
概括
这项研究提出了一个可穿戴的平台来收集和存储汗水随时间的推移,使得健康生物标志物的敏感检测使用表面增强的拉曼散射 (SERS) 外体分析.
科学领域:
- 生物医学工程 生物医学工程
- 分析化学 分析化学
- 可穿戴技术可穿戴技术
背景情况:
- 汗水分析为生理监测提供了一种非侵入性的方法.
- 表面增强拉曼散射 (SERS) 提供了对汗水生物标记物的敏感检测.
- 目前的可穿戴SERS系统受到庞大的设备的限制.
研究的目的:
- 开发一个可穿戴的平台,用于在现场收集汗水和时间序列存储.
- 为了使汗水生物标志物的延迟,体外高灵敏度SERS检测.
- 克服将当前SERS技术集成到可穿戴设备中的局限性.
主要方法:
- 制造了一种具有可湿度梯度的Janus微孔膜,用于定向收集汗水.
- 集成了一个微流体芯片与破裂,用于被动的,时间顺序的汗水采样和储存.
- 开发了一种基于毛细血管的SERS基板,使用银镜反应来检测生物标志物.
主要成果:
- 从皮肤上获得定向和连续的汗水收集.
- 炼期间的汗水样本的时间序列储存.
- 通过SERS使用乳酸和尿素达到低至1mM的检测极限.
- 从人类汗液样本中成功识别出特征性峰值.
结论:
- 开发的可穿戴平台使汗水传感与高性能光谱分析的可行整合成为可能.
- 这项技术为个性化健康监测和动态生理评估提供了有前途的应用.
- 该系统解决了大型拉曼光谱仪在可穿戴健康设备中的不实用性.
相关概念视频
01:14Assessing Body Temperature - Axilla
Procedural Guide for Assessing Axillary Body Temperature using a Digital Thermometer:
Step 1: Perform hand hygiene and put on clean gloves to maintain infection control and prevent cross-contamination.
Step 2: Prepare the patient by explaining the procedure to ensure understanding and cooperation. Ensure privacy, expose the axilla, and inform the patient that minimal movement is crucial for an accurate reading.
Step 3: Adjust the patient’s clothing to expose only the axilla. It minimizes...
Step 1: Perform hand hygiene and put on clean gloves to maintain infection control and prevent cross-contamination.
Step 2: Prepare the patient by explaining the procedure to ensure understanding and cooperation. Ensure privacy, expose the axilla, and inform the patient that minimal movement is crucial for an accurate reading.
Step 3: Adjust the patient’s clothing to expose only the axilla. It minimizes...
01:19Assessing Body Temperature - Temporal Artery
Here is a stepwise guide to assessing the body temperature at the temporal artery using a temporal artery thermometer
Step 1: Perform hand hygiene and don a fresh pair of gloves to prevent cross-infection and ensure patient safety.
Step 2: Explain the procedure to the patient to establish trust. Clear communication establishes trust with the patient, ensures they understand what to expect, promotes cooperation, and enhances comfort during the procedure.
Step 3: Assess the patient's forehead...
Step 1: Perform hand hygiene and don a fresh pair of gloves to prevent cross-infection and ensure patient safety.
Step 2: Explain the procedure to the patient to establish trust. Clear communication establishes trust with the patient, ensures they understand what to expect, promotes cooperation, and enhances comfort during the procedure.
Step 3: Assess the patient's forehead...