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怀孕压力对维斯塔尔大鼠哺乳期后骨和身体组成的影响

M A C Martins^1,2, J A S Monnerat^1,2, G F Teixeira^3,2

¹Laboratório de Nutrição e Metabolismo, Departamento de Nutrição e Dietética, Universidade Federal Fluminense, Niterói, RJ, Brasil.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica

|October 8, 2025

概括

怀孕后期的压力对Wistar大鼠的母体骨健康产生了负面影响,减少了乳房后的骨矿物质密度和强度. 身体组成没有受到压力协议的影响.

科学领域:

生殖生物学生殖生物学
内分泌学在内分泌学.
骨生理学骨生理学

背景情况:

怀孕期间母亲的压力会影响后代的发育和母亲的健康.
妊娠后期压力对母乳哺乳期后母亲骨健康的影响尚不清楚.

研究的目的:

调查怀孕第三周母亲压力对Wistar大鼠母乳养后骨健康和身体组成的影响.
评估骨矿物质密度,强度和血清标记物的变化.

主要方法:

怀孕的Wistar大鼠被分为压力 (SG) 和控制 (CG) 组.
在怀孕的第三周应用了4个刺激的压力协议.
哺乳期后分析了骨矿物质密度,大腿骨强度,血清皮质,OPG,RANKL,和.

主要成果:

压力组的血清皮质水平显著更高,证实了该方案的有效性.
两组之间没有观察到身体组成,OPG,RANKL,或的显著差异.
与对照组相比,压力组表现出较低的骨矿物密度和减少的最大股骨强度.

结论:

孕期压力在哺乳期后对母亲的骨健康产生负面影响,骨矿物质密度和强度的下降证明了这一点.
怀孕期间的压力会影响骨质,尽管整体体质没有变化.

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