孕妇在怀孕期间使用孕激素与子女注意力缺陷多动性障碍风险之间的关联
Elham Bidabadi1, Seyedeh Hajar Sharami2, Seyyedeh Azade Hoseini Nouri1
1Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Journal of attention disorders
|October 8, 2025
概括
怀孕期间使用孕激素似乎与儿童注意力缺陷多动性障碍 (ADHD) 无关,这与一些动物研究相反. 然而,在整个怀孕期间持续暴露于孕激素可能需要进一步调查潜在的关联.
科学领域:
- 生殖健康 生殖健康
- 儿科神经学 儿科神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 动物研究表明,孕激素和注意力缺陷多动障碍 (ADHD) 之间存在联系.
- 关于孕激素对儿童多动症风险的影响的临床数据有限.
- 了解影响神经发育障碍的产前因素至关重要.
研究的目的:
- 临床研究孕妇在怀孕期间使用孕激素与后代患ADHD的风险之间的联系.
- 为了比较患有多动症和健康对照儿童之间的孕激素暴露模式.
主要方法:
- 未来的病例控制研究包括97名ADHD儿童和194名匹配的对照.
- 评估了孕妇在怀孕期间使用孕激素的情况 (假体,注射).
- 使用SPSS进行统计分析,以比较组.
主要成果:
- 在ADHD和对照组之间,总体孕激素使用没有显著差异.
- 在所有怀孕三个月中,持续使用孕激素在ADHD病例中更频繁 (20.0%对4.2%).
- 剖腹产和较低的母亲教育在ADHD组中更为常见.
结论:
- 孕妇在怀孕期间使用孕激素与儿童的多动症发展没有显著的关联.
- 在整个怀孕期间长期暴露于孕激素需要进一步调查潜在的关联.
- 这些发现与一些动物模型数据形成鲜明对比,凸显了对人类临床研究的需要.
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