在罗马的阿片类药物使用和相关的医疗保健结果的流行 IV 在英国的刺激性肠综合征
Mohsin F Butt1,2, Vivek C Goodoory3,4, Cho Ee Ng5
1NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK.
Alimentary pharmacology & therapeutics
|October 8, 2025
概括
大约20%的患有刺激性肠综合征 (IBS) 的人定期使用阿片类药物,尽管指南建议不要用于慢性疼痛. 阿片类药物使用者报告生活质量降低,医疗费用增加.
科学领域:
- 胃肠病学 胃肠病学
- 疼痛管理 疼痛管理
- 公共卫生 公共卫生
背景情况:
- 英国人均阿片类药物处方率很高.
- 国际指导方针建议不要使用阿片类药物治疗慢性非恶性疼痛疾病,如刺激性肠综合征 (IBS).
研究的目的:
- 确定在英国社区环境中被诊断患有罗马四号IBS的个人中经常使用阿片类药物的患病率.
- 评估定期使用阿片类药物对该人口生活质量,心理症状和医疗保健利用的影响.
主要方法:
- 关于人口统计,生活质量 (QoL),心理症状和医疗保健使用情况的数据从752名罗马IVIBS患者中收集到.
- 参与者于2021年7月通过ContactME-IBS英国注册表通过电子邮件招募.
主要成果:
- 在罗马IV型IBS患者中,近20% (19.7%) 报告经常使用阿片类药物,IBS亚型之间没有显著差异.
- 阿片类药物使用者经历了显著降低疾病特异性和通用性QOL,增加焦虑和抑郁,以及更大的整体活动障碍.
- 阿片类药物使用与更高的直接医疗保健费用有关,包括调查,IBS相关药物和计划外的住院治疗.
结论:
- 在英国,定期使用阿片类药物影响了约五分之一的罗马IVIBS患者.
- 与非使用者相比,患有IBS的阿片类药物使用者表现出明显更差的生活质量,更高的心理压力和更高的医疗保健支出.
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