癌组织学和结果的种族差异:来自UroCCR队列的全国性研究
Xiaofan Lu1, Jean-Christophe Bernhard2, Gaëlle Margue2
1Department of Cancer and Functional Genomics, Institute of Genetics and Molecular and Cellular Biology, CNRS/INSERM/UNISTRA, Illkirch, France.
Cancer
|October 8, 2025
概括
细胞癌 (RCC) 的种族差异在法国人群中显示出明显的模式,黑人和非黑人患者之间观察到组织学和分子途径的差异. 这些发现凸显了需要基于祖先的RCC诊断和研究策略的需要.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学是一种遗传学.
- 流行病学 流行病学
背景情况:
- 细胞癌 (RCC) 的种族差异在美国队列中确立,但在欧洲人群中未得到充分探索,特别是在罕见的亚型和通用医疗保健系统中.
- 之前的研究主要集中在常见的RCC亚型上,这在了解较罕见的形式和各种医疗保健环境中的差异方面存在差距.
研究的目的:
- 描述法国RCC组织学,并发症和临床结果中的种族差异.
- 调查RCC中观察到的种族差异的潜在分子基础.
主要方法:
- 来自UroCCR国家注册表的9404名患者 (1987-2024) 的分析,比较了338名黑人和9066名非黑人患有切除术确认的RCC.
- 种族群体之间的临床特征,组织学亚型和结果的比较.
- 使用公开可用的RNA测序数据从非新发性脏组织评估转录组差异.
主要成果:
- 黑人患者中清洁细胞RCC的发病率较低 (47.6%vs. 68.8%),乳头,转位和烟酸酸酶缺乏RCC亚型的发病率较高.
- 黑人患者被诊断年轻,较小,早期的瘤,并更频繁地接受了部分切除术.
- 没有发现疾病特异性存活率的差异;然而,黑人患者的远程无复发存活时间更长 (HR=0.54,p=0.019),可能是由于早期诊断. 转录组分析显示,种族群体之间存在明显的路径丰富.
结论:
- 在RCC组织学和生物学中,不同的种族模式可能会影响对特定RCC亚型的敏感性.
- 这些发现支持开发RCC诊断和研究的祖先知情策略,以解决观察到的差异.
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