多omics分析揭示了缺血性中风中的关键微生物和代谢变异:对肠道和口腔微生物群的洞察
Lihe Yao1,2, Lei Li1, Jun Chen2
1The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
Archives of microbiology
|October 8, 2025
概括
缺血性中风 (IS) 与口腔和肠道微生物失衡有关. 这些部位之间的细菌转移和改变的新陈代谢,特别是减少的短链脂肪酸 (SCFA),可能会通过口腔肠轴促进中风的发展.
科学领域:
- 微生物学 微生物学
- 神经学 神经学
- 代谢学 代谢学 代谢学
背景情况:
- 肠道和口腔微生物群失生症与缺血性中风 (IS) 的发病有关.
- 免疫和代谢途径是将微生物失衡与IS联系起来的潜在机制.
研究的目的:
- 为了研究IS患者口腔和肠道之间的微生物转位.
- 评估这种转移对IS病变的功能代谢影响.
主要方法:
- 分析了32名IS患者和25名对照患者的肠道和口腔下膜斑样.
- 利用PacBio 16S rRNA全长基因测序进行微生物组分析.
- 采用非向的代谢学来分析肠道代谢物.
主要成果:
- 在IS患者中,口腔病原体 (Porphyromonas,Fusobacterium) 和口腔和肠道微生物之间共享的属 (例如Streptococcus,Fusobacterium) 呈现.
- 在IS患者的肠道微生物群显示多样性增加,失生症,减少SCFA产生细菌,以及丰富的机会性病原体.
- 代谢分析显示,SCFA (酸盐) 降低和L-酸盐增加,与微生物变化相关.
结论:
- IS与明显的口腔和肠道微生物失调症有关,这些微生物因细菌转位而相互连接.
- 代谢障碍,包括SCFA和氨基酸水平的变化,可能会将微生物失调与中风的病原性联系起来.
- 口腔肠轴通过微生物和代谢失调在IS发育中发挥着重要作用.
更多相关视频
08:51Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
Published on: September 20, 2024
2.0K
08:22Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model
Published on: June 20, 2025
434
相关概念视频
Methods to Assess Microbial Communities
Microbial communities, comprising bacteria, archaea, and eukaryotic microorganisms, inhabit diverse ecosystems and play crucial roles in environmental and biological processes. Their diversity is defined by three main parameters: species richness (the number of distinct species), species abundance (the relative quantity of each species), and species evenness (how uniformly individual species are distributed in various locations). These factors together shape the structure and ecological balance...
Introduction to the Human Microbiota
Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity, and disease...
The Oral Microbiota
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
Development of the Oral Microbiota
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
Ischemic Stroke l: Introduction
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
