Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Acellular Adipose Tissue promotes anti-fibrotic remodeling in Phase II Study.

medRxiv : the preprint server for health sciences·2026
Same author

Reprogramming the melanoma tumor immune microenvironment via combinatorial signal 2/3 gene delivery.

Journal for immunotherapy of cancer·2026
Same author

AstroID resource: a scalable, relational database structure for longitudinal biomarker discovery.

Journal for immunotherapy of cancer·2025
Same author

Society for Immunotherapy of Cancer: Standards for Reporting of Multiplex Immunohistochemistry/Immunofluorescence Assays (STORMI).

Journal for immunotherapy of cancer·2025
Same author

Effect of systemic glucocorticoid immunosuppression timing, dose, and duration on overall survival among immune checkpoint inhibitor recipients: a retrospective multicohort study.

medRxiv : the preprint server for health sciences·2025
Same author

Transparency and Representation in Clinical Research Utilizing Artificial Intelligence in Oncology: A Scoping Review.

Cancer medicine·2025

相关实验视频

Updated: Jan 15, 2026

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

5.4K

空间蛋白质组学用于研究固体瘤抵抗机制.

Xin Ming M Zhou1,2, Anjali J D'Amiano1, Charles Lu1

  • 1Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.

Cancer metastasis reviews
|October 8, 2025
PubMed
概括

空间蛋白质组学揭示了瘤免疫微环境如何驱动癌症耐药性. 了解免疫抑制细胞的理解

关键词:
抗癌能力 抗癌能力免疫治疗是一种免疫疗法.蛋白质组学是指蛋白质组学.空间生物学 空间生物学

更多相关视频

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
08:08

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

16.9K
Dual-modality Molecular Cartography: Integrating Multiplex mRNA Detection with Protein Imaging Mass Cytometry
06:51

Dual-modality Molecular Cartography: Integrating Multiplex mRNA Detection with Protein Imaging Mass Cytometry

Published on: November 14, 2025

287

相关实验视频

Last Updated: Jan 15, 2026

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

5.4K
Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
08:08

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

16.9K
Dual-modality Molecular Cartography: Integrating Multiplex mRNA Detection with Protein Imaging Mass Cytometry
06:51

Dual-modality Molecular Cartography: Integrating Multiplex mRNA Detection with Protein Imaging Mass Cytometry

Published on: November 14, 2025

287

科学领域:

  • 瘤学和免疫学
  • 蛋白质组学和生物信息学

背景情况:

  • 空间蛋白质组学提供了瘤免疫微环境的单细胞分辨率,这对于癌症生物学和治疗反应预测至关重要.
  • 治疗耐药性仍然是一个重大挑战,限制了当前癌症治疗的疗效,如免疫检查点抑制剂.

研究的目的:

  • 审查当前的空间蛋白质组学和用于研究瘤免疫微环境的计算工具.
  • 讨论空间蛋白质组学如何阐明各种瘤类型的癌症抵抗机制.
  • 突出免疫抑制细胞在调解癌症耐药性的作用.

主要方法:

  • 使用空间蛋白质组学技术对瘤免疫微环境进行分析.
  • 空间蛋白质组学数据的计算分析.
  • 对现有关于空间生物学和癌症耐药性的文献进行审查.

主要成果:

  • 空间蛋白质组学识别了关键细胞种群及其在固体瘤中的相互作用.
  • 通过精确确定免疫抑制细胞局部和蛋白质特征,阐明癌症抵抗机制.
  • 展示空间蛋白质组学在理解多种癌症类型治疗耐药性的实用性.

结论:

  • 空间蛋白质组学对于剖析复杂的瘤免疫微环境和抵抗机制至关重要.
  • 研究免疫抑制细胞局部化和相互作用是克服癌症抗性的关键.
  • 未来人工智能/机器学习和多态学方面的进步将进一步增强空间生物学在癌症研究中的作用.