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在癌症和全身化疗后,单胞胎胚胎移植结果

Johanna Suskin^1,2, Keri Bergin^3,4, Morgan Baird⁵

¹Icahn School of Medicine at Mount Sinai, 1 Gustave Levy Place, New York, NY, 10029, USA.

Journal of assisted reproduction and genetics

|October 8, 2025

概括

在化疗后接受单个胚胎移植 (SEET) 的妇女与对照组相比,怀孕成功率相似. 需要进一步研究使用化疗后卵细胞对生育结果的潜在影响.

科学领域:

生殖医学生殖医学
在瘤学瘤学.
遗传学是一个遗传学.

背景情况:

系统化疗可能会导致性腺毒性,可能会影响未来的生育能力.
有限的数据存在于单个euploid胚胎移植 (SEET) 后的怀孕结果在有化学疗法史的患者.

研究的目的:

为了评估接受化疗后接受SEET的患者的怀孕结果.
将这些结果与没有化疗史的对照组进行比较.

主要方法:

一项回顾性队列研究将55个SEET循环与32名先前接受化疗的患者的165个控制循环相匹配.
匹配标准包括卵细胞年龄,SEET时的年龄,BMI和年龄.
统计分析包括威尔科克森等级,奇平方和调整后勤回归. 一项子分析比较了化疗前和后检索的卵细胞.

主要成果:

在化疗组 (56.4%) 和对照组 (57.0%) (p=0.94) 之间,持续怀孕/活产率相似.
在化疗组中,子宫内膜厚度显著降低 (8毫米 vs. 9毫米; p=0.02).
小组分析没有显示使用化疗前和后卵子细胞的统计差异,但观察到使用化疗后卵子细胞的结果较差的趋势.

结论:

在SEET后的怀孕结果对于有或没有先前化疗史的患者来说是相似的.
需要进行进一步的研究,以了解在使用化疗后获取的卵细胞时成功率降低的潜在趋势.
了解化疗对生育能力的影响对于癌症幸存者护理至关重要.

关键词:

艺术艺术艺术艺术癌症癌症癌症癌症化疗化疗是一种化学疗法.单个幼胚胎的胚胎转移

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