在患有急性淋巴细胞白血病的儿童的诱导治疗期间高血压的发生率
Yamini Karanam1, Amita Trehan1, Deepak Bansal2
1Pediatric Hematology-Oncology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Indian pediatrics
|October 8, 2025
概括
在儿童急性淋巴细胞白血病 (ALL) 诱导治疗期间,系统的血压监测显示了58.7%的高血压发病率,主要是在前两周. 定期监测对于早期检测和管理至关重要.
科学领域:
- 儿科瘤学 儿科瘤学
- 儿童的心血管健康问题
- 血液学 血液学 血液学
背景情况:
- 高血压是儿童急性淋巴细胞白血病 (ALL) 诱导治疗期间的潜在并发症.
- 由于不一致的血压监测,在ALL诱导疗法期间高血压的发生率和时间不清楚.
- 及早发现高血压对于预防相关并发症至关重要.
研究的目的:
- 估计在接受ALL诱导治疗的儿童中高血压的发生率.
- 为了比较前性监测队列和后性分析队列之间的高血压率.
- 为了确定诱导治疗期间高血压发病的时间.
主要方法:
- 一项宏观的观察性研究比较了两组患有ALL的儿童.
- 预期队列:46名儿童每周使用辅导方法监测血压.
- 追溯队列:160名儿童,对偶然检测到的高血压或PRES的病例档案进行了审查.
主要成果:
- 预期队列中的高血压发病率 (58.7%) 与回顾队列中的高血压发病率 (12.5%) (P < 0.001) 相比显著更高.
- 预期队列中大多数高血压病例 (92.6%) 发生在诱导后的前两周内.
- 后回性脑病综合征 (PRES) 很少见,前性队列中有0例,后性队列中有2例.
结论:
- 儿童ALL诱导治疗期间高血压的发生率很大 (58.7%),在最初的两周内达到顶峰.
- 系统的血压监测对于在接受ALL诱导化疗的儿童中早期发现高血压至关重要.
- 在诱导治疗期间,应将例行血压评估纳入儿科ALL患者的护理.
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