对Bifidobacterium longum亚种进行查和遗传分析. 长管二-X用于IBD缓解缓解IBD缓解
Yanqing Hao1, Wanjin Hu1, Weiyang Chen1
1Laboratory of Microbiology, Immunology, and Metabolism, DiPROBIO (Shanghai) Co., Ltd., Shanghai, China.
Probiotics and antimicrobial proteins
|October 8, 2025
概括
一种新的Bifidobacterium longum菌株,F05-044-CM-09,在临床前模型中显示出显著的抗炎作用. 这种益生菌候选人有效减少肠道炎症,并为治疗炎症性肠病 (IBD) 提供了一个有前途的新途径.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 目前对炎症性肠病 (IBD) 的治疗有局限性.
- 研究新的治疗策略对于改善患者的治疗结果至关重要.
研究的目的:
- 为了识别和表征Bifidobacterium longum亚种. 长菌株具有抗炎性质. 长菌株具有抗炎性质.
- 在肠道炎症的临床前模型中评估F05-044-CM-09所选菌株的疗效和安全性.
主要方法:
- 对17种来自人类的Bifidobacterium longum亚种进行查. 使用脂聚糖 (LPS) 诱导的RAW264.7巨细胞炎症模型.
- 对所选菌株F05-044-CM-09进行基因分析,以确定潜在的抗炎机制.
- 对毒性和D-乳酸盐生产基因的安全性评估.
- 在硫酸 (DSS) 诱导的小鼠结肠炎模型中对F05-044-CM-09的评估.
主要成果:
- 菌株F05-044-CM-09在体外表现出优异的氧化物 (NO) 和瘤亡因子-α (TNF-α) 生产的抑制.
- 基因分析显示F05-044-CM-09中有一个CHAP域基因,这表明免疫调节的潜力.
- 在体内,F05-044-CM-09显著改善了DSS诱导的大肠炎症状,包括体重减轻和结肠缩短.
- F05-044-CM-09降低了结肠TNF-α度和LPS水平,表明炎症和细菌转移减少.
结论:
- 双细菌长子物种 双菌长子物种 长F05-044-CM-09具有显著的抗炎作用和有利的安全性.
- 这种菌株是开发用于治疗炎性肠病 (IBD) 的新型益生菌的有希望的候选人.
- 对其免疫调节机制的进一步研究可能会为肠炎开启新的治疗可能性.
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