通过在位顺序矿化,通过沉积保护性视觉治疗纳米涂层来产生超神细菌
Shixiong Chen1, Beibei Sun2, Lingling Lin2
1Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Science advances
|October 8, 2025
概括
研究人员开发了一种具有保护性纳米涂层的超神经细菌,用于增强口腔细菌疗法. 这项创新允许实时监测,并通过双模式成像和治疗行动提高治疗效率.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 微生物学 微生物学
背景情况:
- 口服细菌疗法看起来很有前途,但缺乏实时监测和一致的疗效.
- 目前的方法在胃肠道过境期间难以保护治疗细菌.
研究的目的:
- 开发能够同时监测治疗和增强治疗结果的创新性治疗细菌.
- 用一种保护性纳米涂层来设计细菌,以改善体内生存和功能.
主要方法:
- 顺序的in situ矿化,在细菌上制造双层纳米涂层:内部的二氧化/氧化铁层和外部的碳酸层.
- 利用金属离子吸附和核化进行精确的纳米涂层沉积.
- 评估外层对胃酸的保护作用和内层的成像/治疗能力.
主要成果:
- 外部碳酸层有效地中和了胃酸,保持了细菌的生存能力.
- 内部的二氧化/氧化铁层使双模式 (T1/T2) 磁共振成像能够实现实时细菌跟踪.
- 离子释放促进了病变特异性T1加权成像,该层显示了超氧化物脱酶和酶活动,增强了治疗效果.
- 在大肠炎和动脉样硬化的小鼠模型中成功应用.
结论:
- 开发的治疗性细菌平台为先进的口腔细菌疗法提供了强大的方法.
- 这一创新集成了诊断和治疗,为更有效和可监控的细菌治疗铺平了道路.
- 纳米涂层策略增强了细菌的生存,并提供多模式成像和治疗功能.
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