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可光激活的免疫刺激纳米工程微藻用于增强级联激活的抗瘤免疫力

Shuiling Chen^1,2, Ming Li^1,2, Yu Zhang^1,2

¹Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, China.

Science advances

|October 8, 2025

概括

纳米工程微藻 (PCC@AuNP) 通过触发细胞死亡和重编程瘤微环境 (TME) 来提高抗癌免疫力. 这种创新方法提供了一种安全有效的癌症免疫治疗策略.

科学领域:

生物医学工程生物医学工程
免疫学免疫学免疫学
材料科学材料科学材料科学

背景情况:

瘤免疫性和免疫抑制性瘤微环境 (TME) 限制了癌症免疫疗法的有效性.
制定增强抗瘤免疫反应的策略至关重要.

研究的目的:

开发一种可光激活的免疫刺激剂,用于增强癌症免疫治疗.
同时增加瘤免疫性和重塑免疫抑制TME.

主要方法:

纳米工程微藻 (PCC@AuNP) 被开发为可光激活的免疫刺激剂.
研究的机制包括光催化生成,光合成氧生产和乳酸耗尽.
在体内研究评估了瘤根除,全身免疫力和生物安全性.

主要成果:

PCC@AuNP诱导了强大的免疫细胞死亡,通过内分泌网膜应激和线粒体功能障碍.
光合作用氧和耗尽的乳酸缓解了TME免疫抑制.
观察到增强的细胞毒性T淋巴细胞活性,减少免疫抑制细胞,以及M2到M1巨细胞再极化.
PCC@AuNP消除了原发性瘤,并引起了全身抗瘤免疫,没有可观察到的毒性.

结论:

PCC@AuNP平台有效地增强瘤免疫性,并重塑TME.
这种方法提供了一种安全有效的癌症免疫治疗策略.
PCC@AuNP代表了一种先进的级联增强气体驱动免疫疗法,具有卓越的精度和生物安全性.

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