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在生物活性玻璃颗粒的sol-gel合成过程中改变pH值及其对结构和抗菌特性的影响

Danielle L Perry¹, Anthony W Wren¹

¹Kazuo Inamori School of Engineering, Alfred University, Alfred, NY, USA.

Journal of biomaterials applications

|October 8, 2025

概括

生物活性玻璃的合成依赖于pH值. 3.65的pH值产生了最高的铜离子释放和大肠杆菌抑制,证明了针对抗菌应用的定制生物材料特性.

科学领域:

材料科学材料科学材料科学
生物材料工程生物材料工程
溶凝化学化学化学

背景情况:

溶前体的pH值极大地影响了溶凝玻璃的形成,影响了反应动力学和最终材料特性.
生物活性玻璃是必不可少的生物材料,可用于骨再生和抗菌涂层.
从生物活性玻璃中控制离子释放是调节生物反应和治疗疗效的关键.

研究的目的:

为了研究不同酸性pH值 (2, 3, 3.65, 5, 5.65) 对sol-gel生物活性玻璃合成的影响.
为了将合成玻璃的结构和化学特性与它们的离子释放配置和抗菌活性相关联.
为了优化sol-gel过程,提高生物活性玻璃的功能性质.

主要方法:

生物活性玻璃的sol-gel合成,在不同的pH值下具有特定的成分 (45SiO2-14.5NaO2-14.5CaO-6P2O5-10ZnO-5CuO-5CoO mol%) .
使用拉曼光谱进行结构分析 (Q2和Q3物种),ICP-OES用于模拟体液 (SBF) 中的离子释放.
对大肠杆菌的抗菌活性和表面积分析的评估.

主要成果:

2的pH值导致了最高的表面积 (26.23 m2/g) 和累积的孔表面积 (34.78 m2/g).
拉曼光谱显示在pH 2和3.65.5时,Q3物种强度更高.
在pH值3.65合成的玻璃表现出最高的Cu2+释放 (100mg/L在SBF中1000小时后) 并显示出最显著的大肠杆菌抑制 (48小时).

结论:

索尔的pH值是一个关键参数,它显著影响索尔凝生物活性眼镜的结构特征,离子释放和抗菌功效.
3.65的pH值是合成具有增强铜离子释放和强大的抗菌特性对大肠杆菌的生物活性玻璃的最佳值.
这些发现突出了pH控制的sol-gel合成的潜力,以定制生物活性玻璃用于特定的生物医学应用,特别是在对抗细菌感染方面.

关键词:

它是一种抗菌药物,具有抗菌作用.生物活性玻璃玻璃的使用.离子释放释放离子它们的pH值为pH.阳光凝的使用方法 sol-gel

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