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Updated: Jun 19, 2026

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
10:09

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Published on: January 7, 2019

结合绕过p53的药物来治疗TP53突变白血病

Sudipta Biswas1, Zeinab Albadry M Zahran1,2, Xiaorong Gu1

  • 1Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH.

Blood advances
|October 8, 2025
PubMed
概括

使用特里弗卢诺米德向皮里米丁合成,可以规避TP53突变AML中对低甲基化剂的耐药性. 定时,间歇的DHODH和DNMT1抑制方案为治疗耐药AML提供了一种非细胞毒性方法.

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