RSC4All作为一种机器学习的诺米图,用于预测RSClinTM在HR+/HER2-节点负的早期乳腺癌中产生的结果
F Jacobs1, S D'Amico2, E Ferraro3
1Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
ESMO open
|October 8, 2025
概括
在早期乳腺癌中,RSC4All准确地预测了远程复发风险和化疗效益,反映了RSClinTM的性能. 这种可访问的工具有助于在RSClinTM无法使用的情况下做出治疗决策.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 机器学习 机器学习
背景情况:
- RSClinTM 结合了临床病理学和基因组数据来预测远程复发 (DR) 风险和化疗 (CT) 益处,用于节点-阴性 (N0) 激素受体 (HR) -阳性/人表皮生长因子受体2 (HER2) -阴性早期乳腺癌 (eBC).
- 由于监管约束,RSClinTM在欧洲无法使用,因此需要找到替代解决方案.
- RSC4All是为了复制RSClinTM预测并评估其临床影响而开发的.
研究的目的:
- 开发和验证RSC4All,一种机器学习 (ML) 编程,可以准确地复制RSClinTM对DR风险和CT益处的预测.
- 将RSC4All的临床影响与现有的复发率评分 (RS) 和RSClinTM分类进行比较.
- 为欧洲的临床医生和患者提供免费可访问的工具.
主要方法:
- 来自三个欧洲模型开发和内部验证中心的290名HR阳性/HER2阴性eBC患者的回顾性分析.
- 外部验证使用513名患者的独立队列.
- 使用ROC AUC和R平方的性能评估;使用科恩的卡帕和麦克纳马的测试评估的临床协议.
主要成果:
- ML模型取得了出色的性能 (ROC AUC 0.99用于分类,R平方 0.82/0.77用于回归).
- 外部验证证实了高准确性 (ROC AUC 0.99,R平方 0.82/0.76) 和与RSClinTM (科恩卡帕 0.87/0.84) 接近完美的临床一致性.
- RSC4在93%以上的案例中,所有复制的RS到RSClinTM重新分类模式;一个基于网络的工具是公开的.
结论:
- RSC4All准确地复制了RSClinTM的预测和重新分类模式,在RSClinTM无法访问的情况下提供了可行的替代方案.
- 该工具改进了风险分层,并支持在N0HR阳性/HER2阴性eBC中辅助治疗决策.
- 外部验证支持RSC4All的通用性和临床适用性.
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