系统性免疫炎症指数和老年人中风之间的反转U形曲线关系:基于人口的研究
Jinming Fan1, Junzhu Zhang2, Jiawen Chen1
1Center of Cerebrovascular Disease, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong Province, China; Center of Interventional Medicine, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong Province, China.
系统性免疫炎症指数 (SII) 显示了老年人中逆转的U形关联与中风风险. 较高的SII水平最初会增加中风风险,但超过一定的门,较高的SII与风险降低有关.
科学领域:
- 老年学是指老年学的学科.
- 心血管健康 心血管健康
- 免疫学 免疫学 免疫学
背景情况:
- 系统性免疫炎症指数 (SII) 是一种新兴的系统性炎症生物标志物.
- 了解像SII这样的炎症标志物对于识别老年人群中风风险因素至关重要.
研究的目的:
- 调查系统性免疫炎症指数 (SII) 与老年人中风发病率之间的关联.
- 探索SII作为中风风险预测生物标志物的潜力.
主要方法:
- 国家健康和营养检查调查 (NHANES) 数据 (2017-2020) 的横截面分析.
- 使用多变量回归,平滑曲线拟合和值效应分析.
- 根据主要的人口和临床因素进行调整,包括年龄,种族,教育,心脏病,高血压,高脂血症,糖尿病和吸烟状况.
主要成果:
- 在SII和中风之间观察到一个反转的U形关系.
- 在0.894 (10^6细胞/μl) 的SII值以下,增加的SII与明显更高的中风风险相关 (OR=2.813).
- 在这个值以上,增加的SII与明显降低的中风风险相关 (OR=0.349).
结论:
- 这项研究揭示了老年人SII和中风之间的反向U形关联.
- 虽然由于横截面设计无法确定因果关系,但研究结果强调了SII在中风风险中的复杂作用.
- 这项研究为未来的研究提供了基础,旨在根据炎症标志物识别基于中风的高风险人群.
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