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聚二对外围和中央听觉系统的影响

Nathiya Vaithiyalingam Chandra Sekaran¹, Susan L Schantz², Daniel A Llano³

¹Department of Molecular and Integrative Physiology, Urbana, IL, USA; Beckman Institute for Advanced Science and Technology, Urbana, IL, USA.

Hearing research

|October 8, 2025

概括

在发育过程中暴露于多双 (PCB) 会导致永久性的听力缺陷,影响耳朵和大脑. 本综述强调了PCB对听力和神经发育的风险,强调了与噪音暴露的累积效应.

科学领域:

神经科学是一个神经科学.
环境健康环境健康
毒理学毒理学毒理学

背景情况:

聚二 (PCB) 是一种持久性内分泌干扰化学物质,在环境中广泛分布.
在神经发育关键时期的暴露对感官系统,特别是听觉处理构成风险.
PCBs 生物累积,它们的脂性使它们更容易进入神经组织.

研究的目的:

审查关于PCB对听觉功能的影响的人类流行病学研究和动物模型.
检查PCB对外围和中央听觉通路的影响.
了解PCB对听觉系统的多层次影响.

主要方法:

对人类流行病学数据的审查,将PCB暴露与听力损伤联系起来.
动物模型研究的分析,调查PCB对听觉脑干反应 (ABR) 和耳声排放 (DPOAEs) 的影响.
检查神经成像和电生理学数据的中央听觉通路变化.

主要成果:

在孕期和生命早期暴露于PCB会导致永久性的听力缺陷.
有证据表明,耳外毛细胞功能障碍 (降低DPOAE和ABR) 可能是由于氧化应激.
中央听觉通路的改变 (听觉皮层,下结) 包括断的音位组织和神经可塑性受损,有时超过外周缺陷.
人类数据将特定的PCB同源与儿童听力损失风险的增加联系起来.
结合PCB和噪声暴露导致累积的听觉处理缺陷.

结论:

暴露于PCB会在多个层面上对听觉系统产生重大影响,从耳到中央处理.
中央听觉的漏洞甚至可以表现为正常的外周听觉功能.
对分子机制和人群特异性影响的进一步研究对于风险评估和公共卫生政策至关重要.

关键词:

审计委员会审计委员会审计委员会听觉皮层中的听觉皮层.听力损失听力损失在下面的colliculus.在中脑中,大脑中部这就是为什么PCB PCB.

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