在中国南部儿童中EDC的特征与阻塞性睡眠呼吸暂停有关
Lixin Zhou1, Suhan Wang2, Dongcai Li3
1Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.
Environment international
|October 8, 2025
概括
环境内分泌干扰化学物质 (EDC) 与儿童阻塞性睡眠呼吸暂停 (OSA) 有关. 这项研究发现EDC混合物,特别是酸盐和有机酸盐阻燃剂,加剧了儿科OSA的严重程度和较低的氧和度.
科学领域:
- 环境健康 环境健康
- 儿科睡眠医学 儿科睡眠医学
- 毒理学 毒理学 毒理学
背景情况:
- 儿童阻塞性睡眠呼吸暂停 (OSA) 是一种普遍存在的睡眠障碍,对健康有重大影响.
- 中国面临着高负担的OSA,全球有1.76亿患者.
- 环境内分泌干扰化学物质 (EDC) 在儿科OSA中的作用尚不清楚.
研究的目的:
- 调查中国南部各种EDC暴露与儿童OSA之间的关联.
- 确定特定的EDC和EDC混合物,有助于小儿OSA的发病.
- 评估EDCs对多睡眠学衍生睡眠呼吸暂停指数的影响.
主要方法:
- 从深的第三级睡眠诊所招募了334名年龄≤15岁的儿童队列.
- 使用HPLC-MS/MS,对34种EDC进行量化,包括有机酸盐阻燃剂 (OPFR), parabens,phthalate代谢物 (PAE),benzophenones (BPs),合成酸氧化剂 (SPA) 和 bisphenols.
- 使用多变量线性回归和基于量子的g计算 (Qgcomp) 来评估单一化学物质和混合物对OSA指数 (如AHI,OAHI,ODI和SpO2) 的影响.
主要成果:
- 多个EDC显示显著的剂量反应关系与增加的呼吸暂停-呼吸暂停指数 (AHI),阻塞性呼吸暂停指数 (OAHI) 和氧气脱度指数 (ODI),以及降低氧气和度 (SpO2).
- EDC混合物与增加的AHI,OAHI和ODI有关,并降低了基线,最低和平均SpO2水平.
- 双乙烯甲酸 (DBP) 对AHI,OAHI和ODI表现出最强烈的负面影响,而二-2-乙烯) 四甲酸 (BCIPP) 对SpO2.2表现出最大的积极影响.
结论:
- 这项生物监测研究提供了第一个证据,表明EDC混合物,特别是酸盐和OPFRs,在儿科OSA的发病过程中发挥作用.
- 调查结果强调需要进行化学政策改革,以减轻环境暴露.
- 需要进行进一步的纵向研究,以阐明将环境暴露与儿童睡眠呼吸障碍联系在一起的生物机制.
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