环境微塑料对典型药品吸收和毒性潜力的衰老主导影响
Tengda Ding1, Zhangming Hou1, Hongfeng Zhou1
1College of Chemistry and Environmental Engineering, Shenzhen University, 518060, Shenzhen, China.
The Science of the total environment
|October 8, 2025
概括
陈旧的微塑料 (MP) 与原始的MP相比,显著增加了药物吸收. 这种相互作用改变了污染物的行为,并降低了一些药物的毒性,如硫甲醇,对水生藻类.
科学领域:
- 环境化学环境化学
- 生态毒理学 生态毒理学
- 材料科学 材料科学 材料科学
背景情况:
- 同时出现的药物和微塑料 (MPs) 由于联合毒性,对水生生态系统构成重大风险.
- 了解污染物相互作用,特别是与老年议员 (A-MP) 相互作用,对于准确的环境风险评估至关重要,但仍然有限.
研究的目的:
- 调查纳素 (NAP),贝扎菲布拉特 (BZF) 和硫甲 (SMX) 在处女和老化聚钢 (PS),聚乙烯二甲 (PET) 和聚乙烯 (PE) 的吸附行为.
- 探索A-MPs对这些药品对水生生物的联合毒性的影响.
主要方法:
- 对于药品,在人工老化前后,对三种类型的MP进行了吸附实验.
- 描述技术和理论计算被用来分析吸附机制 (例如,π-π相互作用,结合).
- 在存在A-MPs的情况下评估了SMX对Dunaliella salina的毒性.
主要成果:
- 老年国会议员的药物吸收能力比原始国会议员高24.3-131.1%.
- 陈旧的PET,PS和PE分别显示了NAP,BZF和SMX的最大吸收率.
- 老化增强了NAP和BZF吸附的π-π相互作用,以及MP上的SMX吸附的键,导致SMX毒性降低.
结论:
- 微塑料的老化显著影响了制药吸附动态和机制.
- 老年MP与药物之间的相互作用可以改变它们的环境风险,可能降低某些化合物的毒性.
- 调查结果提供了对老年国会议员在规范水生环境中制药风险中的作用的关键见解.
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