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Updated: Jan 15, 2026

Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS
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Published on: August 10, 2017

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一个下一代的HDAC6抑制剂用于肌缩侧面硬化和前性痴呆症

Rebecca E James1, Michael Bekier2, Pin-Tsun Justin Lee3

  • 1Eikonizo Therapeutics, Inc., Cambridge, MA 02142, USA.

Brain : a journal of neurology
|October 8, 2025
PubMed
概括

一种新药,EKZ-438,通过选择性抑制HDAC6.6来治疗ALS和FTD等神经退行性疾病,显示出有希望的结果. 这改善了蛋白质静止和细胞内运输,在临床前模型中提供神经保护.

关键词:
这就是ALS.这是一个FTD.这是一种HDAC6抑制剂.轴轴运输是一种轴轴运输.蛋白质稳定症是一种蛋白质稳定症.

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