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新型可注射的三酸盐复合骨水泥,内置抗菌保护

Azadeh Saberi¹, Amir Moeintaghavi², Hossein Bagheri¹

¹Dental Materials Research Center, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran.

Journal of biomaterials applications

|October 8, 2025

概括

硫酸和修改后的纳米-酸增强三酸 (C3S) 水泥的骨修复作用. 修改后的水泥表现出更好的性能,并有效释放菌素,以对抗骨缺陷中的细菌感染.

科学领域:

生物材料科学生物材料科学
材料工程材料工程材料工程
整形外科的研究研究.

背景情况:

生物活性三酸 (C3S) 水泥对于骨缺陷修复至关重要.
提高C3S水泥的抗菌功效和物理化学特性对于治疗受感染的骨缺陷至关重要.
添加特定的添加剂可以调节水泥性能.

研究的目的:

调查硫酸 (CaS) 和改性纳米-酸 (mHA) 对C3S水泥性能的影响.
为了评估修改后的水泥的酸盐形成潜力和抗菌活性.
评估从复合水泥中释放的万科 (VANCO) 的动力学和疗效.

主要方法:

合成的C3S水泥复合材料含有不同的CaS和mHA含量.
特性物理化学性质包括设置时间,流量和可注射性.
评估了微观结构的发展,在PBS中形成 apatite,以及压力强度.
评估了万科米辛释放动力学和对相关病原体的抗菌疗效.

主要成果:

添加CaS显著减少了水泥固时间.
复合水泥符合流量和注射能力的标准要求.
修改后的水泥表现出增强的压力强度,并促进了阿帕层的形成.
从复合物中释放的万科米辛显示出显著的抗菌活性,抑制了细菌的增殖.

结论:

用CaS和mHA修改的C3S水泥显示了改善的物理化学特性和生物活性.
增强的水泥有效地控制了菌素的释放,使其具有持续的抗菌作用.
这些修改后的C3S水泥代表了对骨再生和感染治疗有前途的先进材料.

关键词:

用抗生素加载的水泥装满了抗生素.生物活性骨水泥的生物活性骨水泥.骨缺陷修复骨缺陷修复三酸/硫酸复合物的复合物范科米的药物释放是可以释放的.

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