1997-2019年智利多发性硬化症死亡率的性别趋势
J Arriagada Opazo1, V Farah González1, M González Delgadillo1
1Estudiante de la Escuela Medicina de la Universidad de Talca, Chile.
Neurologia
|October 8, 2025
概括
智利的多发性硬化症 (MS) 死亡率自2005年以来总体下降. 虽然由于人口变化,原始死亡率增加,但实际死于MS的风险显著下降,特别是在男性中.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 全球多发性硬化症 (MS) 患病率正在上升,估计全球约有280万人受到影响.
- 智利于2008年启动了一项针对多发性硬化症修饰疗法的试点计划及其临床实践指南.
- 了解MS死亡率趋势对于公共卫生干预至关重要.
研究的目的:
- 分析1997年至2019年智利多发性硬化症 (MS) 死亡率的趋势.
- 根据智利的性别和地理度对MS死亡率趋势进行分类.
- 评估影响MS死亡率的人口和风险因素.
主要方法:
- 从官方智利卫生统计数据中提取了1997-2019年的MS死亡率数据 (ICD-10,G35).
- 利用国家统计局的人口数据进行分析.
- 使用Joinpoint软件和RiskDiff进行人口结构和死亡风险评估,计算了年龄标准化死亡率 (SMR) 并分析了趋势.
主要成果:
- 智利的MS总体死亡率 (TME) 自2005年以来呈现显著下降趋势.
- 在地理上,北部和中南部地区显示出MS死亡率显著下降的趋势,而南部没有显著下降.
- 原始死亡率的增加 (25%) 是由于人口结构的变化而导致的,相比之下,死亡风险下降了25.46%.
结论:
- 1997-2019年间,智利MS的标准化死亡率 (SMR) 已经下降,只有在北部地区观察到显著下降.
- 尽管由于人口转移而导致原始死亡率上升,但患MS死亡的风险有所降低,特别是在男性中.
- 这些发现突显了区域差异以及人口变化对智利MS死亡率趋势的影响.
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