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Updated: Jan 15, 2026

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment
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肺腺癌的小鼠模型:用于临床前研究的宝贵工具

Wenli Shang1, Caihong Lai1, Shiwen Luo2

  • 1Medical Innovation Center, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330006, China; Huankui Academy, Nanchang University, Nanchang, Jiangxi 330031, China.

Gene
|October 8, 2025
PubMed
概括

这篇评论探讨了肺腺癌 (LUAD) 的小鼠模型,这是一种致命的癌症. 结合像异种移植和GEMM这样的模型可以改善LUAD研究和药物发现.

关键词:
可诱导致癌物质的模型.细胞系衍生异种移植的细胞系.转基因工程的小鼠模型肺部腺癌是肺部的癌症.鼠模型的模型.患者衍生异种移植模型

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Mouse Models of Cancer Study02:43

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
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