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马尔特处理暴露与儿童的代谢疾病风险得分有关

Sonja Entringer1, Malvika Godara2, Ferdinand Hoffmann2

  • 1Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Psychology, Berlin, Germany; Development, Health, and Disease Research Program, University of California, Irvine, Orange, CA, USA; German Center for Mental Health, Berlin, Germany.

Brain, behavior, and immunity
|October 8, 2025
PubMed
概括

儿童虐待暴露与成人心脏代谢疾病和死亡率的较高代谢学风险得分有关. 这些代谢物分析工具可以帮助早期风险预测和干预.

关键词:
童年虐待 童年虐待早期生活中的压力.代谢学 代谢学 代谢学风险分层是指风险的分层.

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Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
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