在暴露于酒精的怀孕中与烟草和大麻或没有烟草和大麻的不良出生结果
Florencia Anunziata1, Jessica Frankeberger1, Rebecca J Baer1
1Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Preventive medicine
|October 8, 2025
概括
产前酒精使用与烟草或大麻相结合,增加了早产和孕期婴儿小的风险. 优先考虑怀孕期间多重物质使用的查对于更好的结果至关重要.
科学领域:
- 产科和妇科 产科和妇科
- 围产期健康 围产期健康
- 药物使用研究研究 药物使用研究
背景情况:
- 怀孕期间使用酒精是不良分娩结果的已知危险因素.
- 伴随疾病的物质使用的影响,特别是大麻和烟草,与酒精一起,需要进一步调查.
研究的目的:
- 评估产前酒精使用诊断,是否同时使用大麻或烟草,以及早产 (PTB) 和小于妊娠年龄 (SGA) 婴儿的风险之间的关联.
- 为了比较仅使用酒精和使用涉及酒精,烟草和/或大麻的多种物质之间的风险.
主要方法:
- 利用加利福尼亚州出生证明数据 (2007-2021年) 与母亲/婴儿住院记录相关.
- 识别的物质使用诊断使用母体ICD9-10代码.
- 对极端/非常PTB,晚期PTB和SGA进行计算的调整风险比率 (aRR) 和95%置信区间 (CI).
主要成果:
- 与单独使用酒精相比,同时使用酒精和烟草会增加极端/非常PTB (aRR=1.44),晚期PTB (aRR=1.25) 和SGA (aRR=1.31) 的风险.
- 酒精和大麻使用增加了SGA风险 (aRR=1.21).
- 三种物质 (酒精,烟草,大麻) 的使用与极度/非常PTB (aRR=1.68) 和SGA (aRR=1.29) 的更高风险有关.
结论:
- 产前接触烟草,有或没有大麻,与酒精使用相结合,显著增加了PTB和SGA的风险.
- 针对产前多物质使用的例行查和干预对于减轻不良妊娠结果至关重要.
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