微生物群:癌症转移治疗的黎明
Shenglong Xia1, Dingjiacheng Jia1, Liangjing Wang1
1Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310058, China; Institution of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang Province, 310058, China.
Trends in molecular medicine
|October 8, 2025
概括
肠道和瘤细菌显著影响癌症转移. 准这些微生物及其代谢物为新型癌症治疗提供了一个有前途的战略.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 癌症研究 癌症研究
背景情况:
- 转移是癌症预后不良的主要驱动因素,受癌细胞-瘤微环境相互作用的影响.
- 肠道微生物群和内细菌在癌症的进展和转移中起着至关重要的作用.
研究的目的:
- 审查微生物群与癌症转移之间的复杂关系.
- 阐明微生物群落影响转移过程的机制.
- 讨论针对癌症干预的微生物群的治疗策略.
主要方法:
- 文献综述侧重于微生物群与癌症转移之间的相互作用.
- 分析微生物代谢物在癌症传播中的作用.
- 探索针对微生物组的新型治疗方法.
主要成果:
- 微生物群通过各种机制显著调节癌症的进展和转移性传播.
- 微生物代谢物是促进癌症传播的关键因素.
- 针对肠道微生物群和内微生态学,显示出新的干预措施的潜力.
结论:
- 微生物组与癌症转移密切相关.
- 微生物代谢物是抗转移疗法的关键标.
- 调节微生物组为缓解癌症转移提供了一个有希望的治疗途径.
相关概念视频
The Tumor Microenvironment
7.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.6K
Metastasis
6.4K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.4K
Tumor Immunotherapy
1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
Drugs that Stabilize Microtubules
2.6K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.6K
Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K


