SMART v10:三十年的蛋白质域注释资源
Ivica Letunic1, Peer Bork2,3,4
1biobyte solutions GmbH, Bothestr 142, 69126 Heidelberg, Germany.
Nucleic acids research
|October 8, 2025
概括
用于蛋白质域分析的简单模块化架构研究工具 (SMART) 平台已通过重新设计的界面和扩展的基因组数据进行更新. 它现在支持超过12,000种物种,并与STRING,eggNOG和KEGG通道集成.
科学领域:
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
- 分子生物学分子生物学
背景情况:
- 简单模块化架构研究工具 (SMART) 是一个重要的基于网络的平台,用于蛋白质域识别和分析.
- 近三十年来,SMART一直是了解蛋白质结构的基石.
- 之前的版本需要更新以增强用户体验和数据集成.
研究的目的:
- 推出SMART版本10,突出其重新设计的用户界面和扩展功能.
- 通过现代网络技术提高SMART平台的直观性和可用性.
- 加强与其他主要生物数据库的数据同步和集成.
主要方法:
- 使用现代网络技术重新设计了用户界面,以提高可用性.
- 与最新的STRING数据库版本同步了"基因组"模式,扩大了物种覆盖范围.
- 整合了 eggNOG 和交互式 Pathways Explorer 版本 3 的最新数据.
主要成果:
- 智能版10提供了一个完全重新设计的,直观的用户界面.
- 基因组注释现在涵盖了12,035个物种,比上次发布大幅增加.
- 增强整合提供了1750万个正统组的链接和最新的KEGG路径数据.
结论:
- 智能版10代表了蛋白质域分析工具的重大进步.
- 更新后的平台提供了显著改进的可用性和数据范围.
- 增强的整合促进了更全面的生物途径和蛋白质架构研究.
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