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在多发性硬化症中选择性S1P受体调节改变了CXCL13:CXCR5相关的免疫活动,但没有影响抗SARS-CoV-2免疫力

Andrea Harrer^1,2, Richard F Radlberger³, Beate Buchegger⁴

¹Department of Neurology, Christian-Doppler University Hospital, Paracelsus Medical University, Centre for Cognitive Neuroscience, EpiCARE, Salzburg, Austria. a.harrer@salk.at.

Neurology and therapy

|October 8, 2025

概括

奥萨尼莫德是一种选择性基-1-酸盐受体调节剂,可降低多发性硬化症 (MS) 患者的CXCL13:CXCR5轴活性. 这种调节保留了抗病毒免疫力,特别是通过CD8+T细胞,这表明MS治疗的安全性是有利的.

科学领域:

免疫学免疫学免疫学
神经科学是一个神经科学.
药理学药理学是指药理学的学科.

背景情况:

氨酸-1-酸盐受体 (S1PR) 调节器用于多发性硬化症 (MS).
非选择性S1PR调节器具有感染风险.
CXCL13:CXCR5轴与MS炎症和保护性免疫有关.

研究的目的:

调查ozanimod选择性S1PR调制是否会影响MS患者的CXCL13:CXCR5轴.
评估ozanimod在SARS-CoV-2大流行期间对抗病毒免疫反应的影响.

主要方法:

20名多发性硬化患者接受ozanimod治疗和10名健康对照者的观察性研究超过1年.
测量CXCR5+ T和B细胞,血清CXCL13,以及3个月间隔的抗SARS-CoV-2免疫反应.

主要成果:

奥扎尼莫德治疗降低了CXCR5+淋巴细胞计数和血清CXCL13水平.
在接种疫苗/感染后,抗SARS-CoV-2抗体和T细胞反应保持不变.
在接受ozanimod治疗的患者中,观察到SARS-CoV-2反应性T细胞从CD4+转变为CD8+.

结论:

使用ozanimod选择性S1PR调制会影响CXCL13:CXCR5轴,可能减少MS相关的炎症.
抗病毒免疫防御似乎被保留,CD8+ T细胞可能会补偿CD4+ T细胞的变化.
免疫学发现表明ozanimod在MS中具有有利的安全性和有效性,适用于其他病毒感染.

关键词:

CXCL13:CXCR5CXCL13:CXCR5CXCL13:CXCR5CXCL13:CXCR5CXCL13:CXCR5CXCL13:CXCR5CXCL13:CXCR5CXCL13:CXCR5CXCL13:CXCR5CXCL13:CXCR5CXCL13:CXCR5CXCR5CXCL13:CXCR5CXCR5CXCL13:CXCR5CXCL13:CXCR5CXCR5CXCL13:CXCR5CXCR5C 多发性硬化症是多发性硬化症.臭氧化的使用方法通过S1PR调制.这就是SARS-CoV-2病毒.

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