患者报告的结果和用于管理阴道松综合征的措施:系统性审查
Hongqin Chen1,2, Jian Meng1,2, Qiao Li1,2
1Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, South Renmin Road, Chengdu, Wuhou district, 610041, China.
Health and quality of life outcomes
|October 8, 2025
概括
对于阴道松综合征 (VRS) 的患者报告结果 (PRO) 和措施 (PROM) 的异质性使研究复杂化. 在VRS治疗中需要标准化,验证的PROM来获得强有力的临床证据.
科学领域:
- 妇产科和产科 妇产科和产科
- 患者报告的研究结果研究结果
- 临床试验方法论 临床试验方法论
背景情况:
- 阴道松综合征 (VRS) 研究受到患者报告结果 (PRO) 和措施 (PROM) 不一致的影响.
- 这种异质性阻碍了跨研究的比较和证据的整合,阻碍了对VRS治疗的强有力的临床证据开发.
研究的目的:
- 在已发表的VRS研究中系统地调查PRO和PROM的使用情况.
- 创建用于VRS研究的现有PRO和PROM的综合目录.
- 为VRS患者选择适当的结果措施和工具提供指导.
主要方法:
- 在主要数据库 (PubMed,EMBASE,Web of Science,Cochrane) 中对VRS治疗研究进行系统的文献搜索,截至2024年12月.
- 提取和编目PRO和PROM,按主题领域分类,重点关注盆地肌肉训练,体能疗法和手术干预.
- 使用COSMIN检查清单评估常用PROM的测量特性.
主要成果:
- 包括69项研究 (4520名参与者),报告了68项PRO和57项PROM.
- 最常见的PROM是女性性功能指数 (FSFI),阴道松调查问卷 (VLQ),视觉模拟量表 (VAS),PISQ-12和SSQ.
- 显著比例的PROM (73.68%) 仅出现一次,81.09%没有得到验证.
结论:
- 手术和非手术VRS治疗的PRO重叠,非手术选择包括额外的疗效和满意度结果.
- 未经验证的PROM的高患病率凸显了在VRS研究中对标准化,疾病特异性的措施的迫切需要.
- 通过Delphi调查和专家共识,预计未来开发VRS的核心成果集 (COS) 和核心成果测量集 (COMS).
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