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Updated: Jan 15, 2026

Substrate Generation for Endonucleases of CRISPR/Cas Systems
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Published on: September 8, 2012

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克里斯普尔-Cas12a REC2-Nuc 相互作用驱动目标链切割并限制跨切割

Anthony Newman1, Aakash Saha2, Lora Starrs1

  • 1The Shine-Dalgarno Centre for RNA Innovation, Division of Genome Sciences and Cancer, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia.

Nucleic acids research
|October 9, 2025
PubMed
概括

克里斯普尔-Cas12a酶表现出不同的DNA切割能力. 了解这些 cis 和 trans 分裂的差异是优化基因组编辑和 DNA 检测技术的关键.

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