血25-氧维生素D度,维生素D缺乏和社区居住的日本成年人的死亡率
Kaori Kitamura1, Yumi Watanabe1, Keiko Kabasawa2
1Division of Preventive Medicine, Niigata University Graduate School of Medical and Dental Scienceshttps://ror.org/04ww21r56, Niigata, Japan.
The British journal of nutrition
|October 9, 2025
概括
血中维生素D水平较低与日本成年人死亡风险增加有关. 这项研究强调了维持适当的25-氧维生素D (25(OH) D度对整体健康的重要性.
科学领域:
- 内分泌学 在内分泌学.
- 流行病学 流行病学
- 老年学是一门学科.
背景情况:
- 血液中的25-基维生素D (25(OH) D) 度呈现季节性和性别差异.
- 维生素D缺乏是一个日益严重的公共卫生问题,与各种健康结果的潜在联系.
研究的目的:
- 研究日本成年人维生素D缺乏和全因死亡率之间的关联.
- 为了确定与死亡率相关的25...OH) D度的特定风险值.
主要方法:
- 一项队列研究涉及8285名年龄在40-74岁之间的日本成年人,随访时间为11年.
- 血25 ((OH) D度在基线测量并使用季节和性别分层的五分位数进行分析.
- 用Cox比例危险模型评估所有原因的死亡率.
主要成果:
- 较低的季节和性别分层的25...OH) D五分位数与增加的全因死亡风险 (P=0.0015) 显著相关.
- 与最高五分位数相比,最低五分位数 (中位数为28.2nmol/l) 的危险比率 (HR=1.46) 高出46%.
- 使用原油五分位数观察到类似的关联,这表明风险值差异大约为10nmol/l.
结论:
- 低血25(OH) D度是日本成年人群中所有原因死亡的重要风险因素.
- 测量原始25 ((OH) D度可能有助于调整与死亡率相关的维生素D缺乏的估计风险值.
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