腰椎间盘的保守补充和替代医学治疗有效性的异质性:潜伏轨迹分析
Eunsan Kim1, Jiyoon Yeo1, Me-Riong Kim2
1Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, 2F, 540 Gangnam-daero, Gangnam-gu, Seoul, 06110, Republic of Korea.
Pain medicine (Malden, Mass.)
|October 9, 2025
概括
腰椎间盘的保守治疗方法显示患者的结果各不相同. 需要个性化策略,因为在接受补充和替代医学的患者中观察到不同的疼痛,残疾和生活质量轨迹.
科学领域:
- 综合医学是一个整体医学.
- 肌肉骨系统疾病 肌肉骨系统疾病
- 临床结果研究研究
背景情况:
- 个性化治疗策略需要了解治疗有效性的患者异质性.
- 保守的补充和替代医学 (CAM) 经常用于腰椎间盘 (LDH).
研究的目的:
- 分析LDH患者治疗保守CAM的疼痛,残疾和生活质量的结果异质性.
- 根据治疗反应轨迹识别患者子组.
主要方法:
- 对996名成年LDH患者的前性观察研究,这些患者有辐射疼痛 (NRS ≥5).
- 患者接受了针,催化剂,,丘纳手动治疗和/或草药.
- 结果 (通过NRS疼痛,通过ODI残疾,通过EQ-5D-5L生活质量) 在基线,14天,出院和6个月后进行评估. 潜伏轨迹分析确定了结果组.
主要成果:
- 732名患者完成了6个月的随访.
- 针对疼痛,残疾和生活质量,确定了两个不同的结果轨迹.
- 大多数患者的疼痛 (90.4%) 和残疾 (85.3%) 得到改善,但生活质量显示出更多的变化 (41.7%改善,58.3%大大改善).
- 较高的基线症状严重程度与更差的预后相关.
结论:
- 患者对LDH的保守CAM反应的异质性很明显.
- 不同的结果轨迹强调了需要个性化的管理方法.
- 识别预后因素可以帮助量身定制治疗以获得更好的结果.
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