与男性乳腺癌相关的因素 前列腺癌幸存者中发生率:退伍军人事务的现实世界证据 国家前列腺癌核心数据
Erum Z Whyne1, Sung-Hee Choi1,2, Nisha Unni2
1VA North Texas Health Care System, Dallas, Texas, USA.
The Prostate
|October 9, 2025
概括
患有前列腺癌的男性退伍军人面临男性乳腺癌的风险增加. 诸如晚期前列腺癌,辐射,抗雄激素剥夺疗法和某些心脏药物等因素会增加这种风险.
科学领域:
- 在瘤学瘤学.
- 心脏瘤学 - 心脏瘤学
- 流行病学 流行病学
背景情况:
- 男性乳腺癌很少见,但退伍军人身份与更高的发病率有关.
- 在男性老兵前列腺癌幸存者中观察到更高的男性乳腺癌患病率.
- 这项研究检查了先前诊断为前列腺癌的退伍军人男性乳腺癌的风险因素.
研究的目的:
- 确定与男性乳腺癌发病率增加风险相关的因素.
- 分析退伍军人事务 (VA) 前列腺癌数据核心的风险关联.
- 调查前列腺癌幸存者的心脏瘤特定风险因素.
主要方法:
- 对300万男性退伍军人进行了回顾性队列研究,他们在VA医院接受了前列腺癌治疗.
- 使用了VA前列腺癌数据核心.
- 在前列腺癌诊断后确定了11,327 (0.86%) 新的男性乳腺癌诊断.
主要成果:
- 较年轻的前列腺癌发病年龄,转移前列腺癌,非西班牙裔黑人种族,辐射和雄激素剥夺疗法 (ADT) 与男性乳腺癌风险增加有关.
- 长期使用心血管疾病 (CVD) 药物,包括罗西米德,螺旋和迪戈辛,显著增加了男性乳腺癌发病率风险.
- 对于已识别的风险因素,计算了危险比率 (HR) 和95%置信区间 (CI).
结论:
- 在诊断前列腺癌时的年龄较小,转移性疾病,辐射,ADT和长期使用特定的心血管疾病药物是老兵幸存者男性乳腺癌的重要危险因素.
- 这些发现突出了前列腺癌幸存者的男性乳腺癌的潜在心脏瘤风险因素.
- 这些见解可以为风险评估和管理策略提供信息.
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