肥胖,葡萄糖代谢和乳腺癌风险之间的独立关联通过不相关的途径
Thi Huyen Trang Nguyen1, Somin Jeon2, Junghyun Yoon2
1Hanyang Institute of Bioscience and Biotechnology, Hanyang University, Seoul 04763, Republic of Korea.
Journal of the National Cancer Institute
|October 9, 2025
概括
肥胖,以体重指数 (BMI) 和腰围 (WC) 衡量,显著增加了绝经后妇女的乳腺癌 (BC) 风险. 禁食血糖 (FBG) 在调解这种关联方面起到很小的作用.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 研究了空腹血糖 (FBG) 在肥胖指标 (体重指数 (BMI) 和腰围 (WC)) 和乳腺癌 (BC) 风险之间的关系中的调解作用.
- 专注于韩国国家乳腺癌查计划中的绝经后妇女.
研究的目的:
- 为了确定FBG是否调解BMI,WC和BC风险之间的关联.
- 为了澄清暴露,媒介和疾病发病的时间序列.
主要方法:
- 利用了2009-2010年期间查的2,093,578名绝经后妇女的数据,并追踪到2021年.
- 采用Cox比例危险回归和调解分析来评估BMI,WC,FBG和BC风险之间的关联.
- 检查了基线BMI和WC作为暴露和FBG水平 (2011-2014) 作为潜在的调解者.
主要成果:
- 较高的BMI (≥30 kg/m2) 和WC (≥88 cm) 与BC风险增加显著相关 (HR分别为1.82和1.43).
- 调解分析显示,FBG对协会的调解很少,约占总影响的5%.
- 超过95%的肥胖指标与BC风险之间的关联归因于受控的直接影响,而不是通过FBG的间接影响.
结论:
- 虽然BMI和WC是BC风险的强有力的预测指标,但FBG的调解作用可以忽略不计.
- 肥胖和葡萄糖代谢似乎独立地影响乳腺癌风险.
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