维生素E对成人血清亚迪波内克和勒素的影响:系统性审查和元分析
Mehdi Karimi1, Sara Alipour2, Samira Pirzad3
1Faculty of Medicine, Bogomolets National Medical University (NMU), Kyiv, Ukraine.
Journal of dietary supplements
|October 9, 2025
概括
补充维生素E并不会显著改变整体皮内克或丁水平. 然而,长期摄入维生素E显示有好处,特别是在非酒精性脂肪肝 (NAFLD) 患者中,通过增加阿迪波内克丁和减少丁.
科学领域:
- 代谢健康 代谢健康
- 营养科学 营养科学
- 内分泌学 在内分泌学.
背景情况:
- 阿迪波涅丁和莱普丁是调节新陈代谢平衡的关键阿迪波金.
- 这些阿迪波金的失调与肥胖,胰岛素耐药性和代谢障碍有关.
- 维生素E是一种抗氧化剂,可能会影响阿迪波金分泌,但证据不一致.
研究的目的:
- 系统地审查和分析口服维生素E补充剂对成人血清阿迪波内克和勒普丁水平的影响.
- 评估维生素E对代谢恒常标志物的影响.
主要方法:
- 在主要的电子数据库中进行了系统的文献搜索,直到2025年8月.
- 确定了符合条件的随机对照试验 (RCT),并提取了数据.
- 聚合效应估计使用加权平均差异 (WMDs) 计算,通过STATA通过95%置信区间 (CI) 计算.
主要成果:
- 总体而言,维生素E补充剂在10个RCT中没有显著改变血清平素 (WMD:0.67 ng/mL; p=0.093) 或瘦素水平 (WMD:-3.60 ng/mL; p=0.067).
- 亚组分析表明,长期补充 (> 12 周) 显著增加了腺素 (p = 0.039).
- 在患有非酒精性脂肪性肝病 (NAFLD) 的患者中,维生素E显著增加了阿迪波涅丁 (p<0.001) 和降低了叶黄素 (p<0.001).
结论:
- 补充维生素E对成年人阿迪波内克丁和莱普丁水平没有显著的整体影响.
- 长期补充维生素E可能对阿迪波涅克水平有益,特别是在NAFLD患者中.
- 由于研究异质性,需要进一步的精心设计的RCT来澄清维生素E的代谢和治疗作用.
关键词:
艾迪波基因 (Adipokine) 是一种可怕的药物.没有任何的Adiponectin勒普丁是一种素.这是一个元分析.肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖托科菲罗尔 (Tocopherol) 是一种可醇.托科特里诺醇 (Tocotrienol) 是一种维生素E 维生素E 是一种维生素.更多相关视频
10:46Characterization of Adipocyte-Derived Extracellular Vesicle Secretion Using a CD63-GFP Reporter Mouse Model In Vivo and In Vitro
Published on: December 5, 2025
206
03:05Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study
Published on: November 21, 2025
477
相关概念视频
01:24Obesity
1.1K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.1K
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
554
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
554
01:31Lipid-derived Compounds in the Human Body
6.2K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
6.2K
01:25Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
246
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
246
01:20Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
166
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
166