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在自闭症谱系障碍中,TNF-α表达与自尊的关联
Yoshinori Kayashima1, Takahira Yamauchi1, Tsutomu Takeda1,2,3
1Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Nara, Japan.
Neuropsychopharmacology reports
|October 9, 2025
概括
瘤坏死因子-α (TNF-α) 水平与患有自闭症谱系障碍 (ASD) 的人的自尊有关. 较低的TNF-α表达与更高的自尊相关联,特别是在ASD中的社会认可和关系方面.
科学领域:
- 神经免疫学 神经免疫学
- 精神病学是一个精神病学.
- 发育神经科学的发展神经科学.
背景情况:
- 自闭症谱系障碍 (ASD) 与免疫功能的改变有关,包括高的炎症标志物,如瘤缩因子-α (TNF-α).
- 自尊,特别取决于外部因素,可能会受到ASD个体的生物学途径的影响.
- 以前的研究表明TNF-α与ASD病理生理学和自尊调节之间存在联系.
研究的目的:
- 调查自尊之间的关系,通过自我价值的偶然性 (CSW) 尺度和个人权力感评估,以及ASD患者的TNF-α表达.
- 为了比较ASD个体与典型发育 (TD) 个体之间的这些关系.
主要方法:
- 51名患有自闭症的高功能个体和34名TD个体参与了这项研究.
- 用日本版本的CSW尺度和个人权力感度来衡量自尊.
- 血TNF-α水平使用ELISA量化,并使用多重回归分析相关性,调整共变量.
主要成果:
- 在患有自闭症的个体中,TNF-α表达与外部CSW领域 (他人认可) 有负相关性,并显示出外观和关系和的趋势.
- 在ASD个体中观察到家庭内个人权力感和TNF-α之间的积极相关性趋势.
- 在TD组中,这些相关性并不显著.
结论:
- TNF-α水平与ASD个体的自尊心有关,特别是在社会环境中.
- 较低的TNF-α表达与与ASD中社会认可相关的更高的自尊心有关,无论自闭症症状的严重程度如何.
- 研究结果表明,在ASD中,炎症过程与心理健康之间存在生物学联系,突出显示了免疫功能的作用.
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