图像在肝细胞癌中的演变作用:从病理分子分析到预后决策
Hanyu Jiang1, Hong Wei1, Lingling Liang1
1Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, China.
Liver cancer
|October 9, 2025
概括
先进的成像技术正在彻底改变肝细胞癌 (HCC) 管理. 现在,成像技术通过评估病态分子驱动因素来帮助个性化治疗选择,超越了简单的瘤负担测量,以获得更好的患者结果.
科学领域:
- 放射学和瘤学 放射学和瘤学
- 人工智能在医学中的应用
背景情况:
- 肝细胞癌 (HCC) 是一种具有异质特征的复杂肝癌.
- 目前的HCC管理通常依赖于一般化的瘤负担,需要更个性化的方法.
- 新的免疫检查点抑制剂疗法需要先进的治疗选择方法.
研究的目的:
- 审查高级成像在肝细胞癌 (HCC) 中不断扩大的作用.
- 探索成像在非侵入性病理分子评估和预后中的应用.
- 讨论在个性化HCC治疗中成像的未来方向.
主要方法:
- 对HCC中先进的成像技术的当前文献的综述.
- 对人工智能应用在桥梁临床前和临床HCC研究中的分析.
- 合成成像在预后,风险分层和治疗选择中的作用.
主要成果:
- 影像正在从监视和诊断演变为个性化病理分子分析.
- 先进的成像技术有助于预测结果和指导治疗决策.
- 人工智能和成像集成为精确,个性化的HCC治疗提供了潜力.
结论:
- 图像对HCC病理分子驱动因素的非侵入性评估起着至关重要的作用.
- 图像应用扩展到预后,风险分层和指导主要治疗选择.
- 需要进一步的研究来解决未满足的需求,并优化未来基于成像的HCC管理.
相关概念视频
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...