母亲临床下甲状腺症与双胞胎怀孕中的生长不一致之间的关联:一项回顾性研究
Bing Zhang1, Xiaoqin Chen1, Xiaoxiao Zhao1
1Department of Neonatal Intensive Care Unit, Xinxiang Central Hospital, Xinxiang, Henan, 453000, People's Republic of China.
International journal of women's health
|October 9, 2025
概括
孕产妇临床下甲状腺功能低下症 (SCH) 与双胞胎生长失调有关. 这项研究发现,SCH是双胞胎出生体重差异的独立风险因素,影响胎儿发育.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 内分泌学 在内分泌学.
背景情况:
- 双胞胎怀孕有患生长不一致的风险,影响约16%的病例.
- 双胞胎的生长失调可能源于母体,胎儿或胎盘因素.
- 亚临床甲状腺功能低下症 (SCH) 是一个潜在的,但尚未研究的,导致双胞胎生长差异的因素.
研究的目的:
- 为了研究母体亚临床甲状腺功能低下症 (SCH) 与双胞胎怀孕中的生长不一致之间的关联.
- 确定SCH是否是双胞胎出生体重异常的独立风险因素.
主要方法:
- 对106名双胞胎怀孕妇女的临床数据进行了回顾性分析.
- 利用线性和逻辑回归模型来评估母亲SCH对双胞胎生长异常的影响.
- 收集关于母亲SCH状态和新生儿生长参数的数据.
主要成果:
- 45.28%的女性患有SCH; 43.40%的双胞胎表现出生长不一致.
- 母亲SCH与更高比例的生长异常 (p=0.005) 和更大的体重差异 (p=0.021) 相关.
- 后勤回归确定母亲SCH为出生体重不一致的独立风险因素 (95%CI:1.601-9.425,p=0.003).
结论:
- 母亲的亚临床甲状腺功能低下症是双胞胎怀孕中出生体重异常的重要危险因素.
- 双胞胎SCH与双胞胎之间出生体重差异的大小有关.
- 进一步研究母亲SCH的管理可能会改善双胞胎怀孕的结果.
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