在冷胚胎转移周期期间,GnRH激动剂在乳腺期支持中使用的协议特异性结果
Anastasia Salame1, Elias M Dahdouh2, Mokhamad Zhaffal3
1Reproductive Endocrinology and Infertility, Fakih Fertility Centre, Al Ain, United Arab Emirates.
International journal of women's health
|October 9, 2025
概括
在冷胚胎转移周期中,添加GnRH激素对质阶段的支持,数量上改善了活产率,并显著增加了植入率. 流产率没有受到影响,这表明对冷胚胎移植结果的潜在好处.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 不孕症治疗方法 不孕症治疗方法
- 辅助生殖技术 辅助生殖技术
背景情况:
- 冷胚胎移植 (FET) 周期旨在通过各种质期支持 (LPS) 策略来优化结果.
- 最近的数据表明,FET中的自然和人工周期产生了与优化的LPS相比较的活产率 (LBR).
- 激素释放激素 (GnRH) 激动剂作为LPS的组成部分被探索.
研究的目的:
- 调查将GnRH激动剂纳入FET循环中的LPS是否可以增强LBR.
- 要确定在FET周期中使用GnRH激动剂是否会降低流产率 (MR).
主要方法:
- 对140个FET循环进行了回顾性分析.
- 循环被分为两组:研究组 (AG) 使用 GnRH 激动剂 (n=66) 和控制组 (NAG) 没有描述的 GnRH 激动剂使用 (n=74).
主要成果:
- 而AG组的植入率显著更高 (61.6%对48.4%,p=0.0413).
- 虽然LBR在AG组数量上更高 (60.6%对47.3%),但它没有达到统计学意义 (p=0.114).
- 流产率在各组之间是相似的 (10%对6.7%,p=0.61).
结论:
- 在FET周期中将GnRH激动剂添加到LPS中,数量上增加了LBR,并显著改善了植入率.
- 流产率没有受到GnRH激动剂使用的显著影响.
- 在人工和排卵诱导FET协议中观察到的效果是可比的.
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