在帕金森病中,冷漠的进展与大脑缩和白质损伤有关
Roqaie Moqadam1,2,3, Houman Azizi2,4,5, Aliza Brzezinski-Rittner2,5,6
1Department of Medicine, University of Montreal, Montreal, Quebec, Canada H3T 1J4.
Brain communications
|October 9, 2025
概括
帕金森病的冷漠性进展与大脑的变化有关. 早期灰质缩和白质强度过高预测了PD患者随着时间的推移而变得更加冷漠.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 老年学是指老年学的学科.
背景情况:
- 漠不关心是帕金森病 (PD) 的常见非运动症状,显著影响患者的生活质量.
- 以前的研究探讨了PD中冷漠的神经相关性,但大脑结构变化和冷漠进展之间的纵向联系尚不清楚.
研究的目的:
- 为了研究区域大脑缩,白质超强度 (WMHs) 和帕金森病患者的冷漠性进展之间的纵向关系.
- 为了确定特定的大脑区域和与随着时间的推移与冷漠的发展和恶化相关的白质变化.
主要方法:
- 利用了来自帕金森病进展标记计划 (PPMI) 的445名新生PD患者的纵向多站点数据.
- 采用T1加权的MRI用于基于变形的形态测量 (DBM) 来评估灰质缩,以及用于WMH细分的脑tISsue细分 (BISON) 算法.
- 应用线性回归用于横截面分析和线性混合效应模型用于纵向分析,控制相关的共变量.
主要成果:
- 在多次比较校正后,没有发现基线大脑结构和冷漠度严重程度之间的显著横截面关联.
- 纵向分析显示,包括核,上叶叶,面,岛叶和小脑在内的区域的基线灰质缩预测了未来的冷漠性进展.
- 增加白质超强度负担,特别是在额叶,与随着时间的推移恶化的冷漠有关.
结论:
- 在特定的大脑区域的基线灰质缩和较大的白质超强度负担是帕金森病中冷漠性进展的显著预测因素.
- 这些发现强调了神经成像标志物的重要性,以了解并潜在地预测PD中冷漠的轨迹.
- 该研究强调了灰质缩和WMHs在帕金森病中无动于衷的纵向发展中的独特作用.
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