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乳酸注会增加人类循环中的亲大脑衍生神经营养因子水平

Julia Röja¹, Nicolas Fiori Ameller¹, Jonathan Grip²

¹Department of Physiology, Nutrition and Biomechanics, The Swedish School of Sport and Health Sciences, Stockholm, Sweden.

Frontiers in cellular neuroscience

|October 9, 2025

概括

乳酸输液增加了循环中的亲BDNF,这是神经可塑性的关键蛋白质,但不是mBDNF. 这表明乳酸可能会调解人类的运动诱导的亲BDNF变化,将运动和大脑健康联系起来.

科学领域:

运动生理学运动生理学
神经科学是一个神经科学.
分子生物学分子生物学

背景情况:

大脑衍生神经营养因子 (BDNF) 对神经可塑性和大脑健康至关重要,其水平随着体育炼而增加.
乳酸盐是运动期间产生的代谢物,被假设为调解运动诱导的BDNF反应,但其孤立的效果是未知的.

研究的目的:

单独研究乳酸对血液和肌肉中的亲BDNF和成熟BDNF (mBDNF) 水平的作用.
为了确定乳酸输液是否影响循环和肌肉BDNF异型.

主要方法:

18名健康志愿者接受了一小时的乳酸或盐水输注.
血液和肌肉样本在输注前,输注期间和输注后最多120分钟内收集.
亲BDNF和mBDNF水平使用ELISA和免疫血栓测试来量化.

主要成果:

与盐水相比,乳酸输液显著提高了血亲BDNF水平55%-68%,在整个康复过程中持续存在.
乳酸注入后血和血清mbbDNF水平没有显著变化.
肌肉亲BDNF水平保持不变,但与I型肌肉纤维面积 (fCSA%) 相相关. 肌肉的mBDNF是无法检测的.

结论:

乳酸单独影响循环中的亲BDNF水平,这表明它可能部分调解运动诱导的亲BDNF增加.
这些发现表明,乳酸在对代谢变化的反应中调节亲BDNF,与mBDNF不同,具有特定的作用.

关键词:

这就是为什么BDNF是BDNF.在BDNF的多态化中.皮质醇是一种皮质醇.纤维是一种纤维类型的纤维.人类人类人类人类人类人类人类乳酸输注是乳酸输注.支持BDNF的人.这是骨肌肉的骨架肌肉.

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