相关实验视频

Updated: Jan 15, 2026

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

红细胞合免疫和输血策略在状细胞疾病:一个单中心分析

Abdulaziz Yusuf^1,2, Abrar Ahmad¹, Hesham A El-Beshbishy³

¹Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

Journal of blood medicine

|October 9, 2025

概括

接受输血的状细胞病患者由于红细胞抗原不相容而面临免疫风险. 扩展表型和国家注册表对于更安全的输血和改善患者结果至关重要.

科学领域:

血液学血液学血液学
免疫学免疫学免疫学
输血医学输血医学

背景情况:

在需要慢性输血的状细胞疾病 (SCD) 患者中,合免疫是显著的并发症.
外来红细胞 (RBC) 抗原暴露会导致抗体产生,使未来的输血复杂化.

研究的目的:

在吉达的索利曼·法基赫医院 (DSFH-J) 的SCD患者中检查ABO和Rh血型表型的分布.
评估这些表型对免疫风险的影响.
为了确定流行的alloantibodies,并强调需要扩展的红细胞表型化.

主要方法:

追溯性研究分析了241名SCD患者的血液组表型.
对检测到的抗体进行分析,包括来自Rh和Kell系统的抗体.
对抗原流行率和抗体频率的评估.

主要成果:

血型O是最常见的 (58.5%),其中93.36%的患者是Rh阳性.
普遍存在的抗体包括抗E (20%) 和抗C (15%),表明Rh不相容.
凯尔系统抗体 (抗K) 在12.5%的病例中被发现,其他alloantibodies也被检测到.

结论:

这项研究强调了需要扩展RBC表型超越ABO和Rh,包括Kidd和Duffy系统,由于观察到的免疫.
建议建立一个具有全面的红细胞抗原数据的国家献血者注册表.
标准化血液查和实施常规扩展的红细胞类型测定对于最小化免疫接种风险和提高沙特阿拉伯患者安全至关重要.

关键词:

红细胞合免疫接种.Rh 现象型 Rh 现象型输血输血输血输血输血状细胞疾病是一种状细胞疾病.

更多相关视频

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

相关概念视频

Multiple Allele Traits

Multiple Allele Traits

The Concept of Multiple Allelism

Blood Transfusion and Agglutination

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...

Blood Transfusion

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...

Disorders of Erythrocytes

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...