整个结核病谱的肠道和肺部微生物群
Rubeshan Perumal1,2, Anou M Somboro1, Juhi Tulsi1
1MRC-CAPRISA HIV-TB Pathogenesis and Treatment Research Unit, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Frontiers in microbiology
|October 9, 2025
概括
结核病 (TB) 是一个由宿主-病原体相互作用影响的全球健康问题. 肠肺微生物群轴在结核病易感性,进展和复发风险方面发挥着至关重要的作用.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 全球健康 全球健康
背景情况:
- 结核病 (TB) 影响全球数以百万计的人,宿主和病原体因素影响疾病.
- 肠道和肺部的微生物群落会影响区域免疫力和结核病的结果.
- 了解宿主微生物群相互作用是解决结核病原学的关键.
研究的目的:
- 探索结核病原发生过程中的肠肺微生物群轴.
- 调查结核病治疗期间和之后的微生物变化.
- 评估微生物群对治疗结果和复发的影响.
主要方法:
- 本综述综合了有关结核病肠肺微生物组轴的现有研究.
- 它检查了结核病患者微生物组成和功能的研究.
- 该审查分析了治疗期间和治疗后微生物组变化的数据.
主要成果:
- 宿主易感性,结核病进展和治疗反应与宿主-病原体相互作用有关.
- 肠肺微生物群轴影响结核病的获得,进展和解决.
- 在结核病治疗期间和之后观察到微生物失生症,影响结核病的结果.
结论:
- 肠肺微生物群轴是结核病原和疾病动态的组成部分.
- 准微生物组可能为结核病治疗和预防提供新的策略.
- 对宿主微生物群交叉的进一步研究对于控制结核病复发至关重要.
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