相关实验视频

Updated: Jan 15, 2026

Human Blastocyst Biopsy and Vitrification

Human Blastocyst Biopsy and Vitrification

Published on: July 26, 2019

单个欧卵母细胞移植后的活产率带有和没有多核胚胎的单个欧卵母细胞移植

Diem Thi Yen^1,2, Nguyen Thi Hue Giang², Le Thi Quyen²

¹Department of Histology and Embryology, Hanoi Medical University, Hanoi, Vietnam.

Medical archives (Sarajevo, Bosnia and Herzegovina)

|October 9, 2025

概括

在IVF中早期胚胎多核化与较低的euploidy和较高的马赛克率有关. 然而,具有这种特征的繁体胚胎仍然表现出与没有这种特征的胚胎相似的活产成功,这表明IVF结果的潜在可管理因素.

科学领域:

胚胎学胚胎学
生殖医学生殖医学
遗传学是一个遗传学.

背景情况:

胚胎发育早期的多核化是体外受精 (IVF) 过程中常见的现象.
双细胞阶段多核化 (2MN) 对染色体健康和活产率的影响尚不清楚.

研究的目的:

为了确定2MN是否与植入前遗传测试 (PGT-A) 检测到的染色体异常相关.
评估2MN与单个幼胚胎移植后活产结果之间的关系.

主要方法:

一项前性研究涉及152名试管婴儿患者从2023年1月至12月.
卵细胞培养和监测使用时间间隔成像.
PGT-A分析胚芽细胞,以评估染色体状况.

主要成果:

23.3%的胚胎显示为2MN.
与非多核化组相比,2MN组的euploidy率 (36.0%) 显著降低,马赛克主义率 (42.6%) 高于非多核化组 (46.3%和31.1%,分别).
转移欧胚胎后的活产率在2MN (62.3%) 和非多核 (61.8%) 组之间没有显著差异.

结论:

早期的多核化 (2MN) 与减少的胚胎繁体化和增加的马赛克主义有关.
来自2MN胚胎的欧体胚胎表现出与没有早期多核化的胚胎相似的活生生的潜力.
该研究对活产子结果的样本大小是一个局限性,需要进一步调查.

关键词:

欧普洛伊迪症是什么意思?在体外受精 (IVF)活生生的出生是活生生的出生.马赛主义 (Mosaicism) 是一个教派.多核化是多核化的一种.在植入前对阳积体的基因检测 (PGT-A)时间缩影是时间缩影.

更多相关视频

Modified MicroSecure Vitrification: A Safe, Simple and Highly Effective Cryopreservation Procedure for Human Blastocysts

Modified MicroSecure Vitrification: A Safe, Simple and Highly Effective Cryopreservation Procedure for Human Blastocysts

Published on: March 2, 2017

Double In Utero Electroporation to Target Temporally and Spatially Separated Cell Populations

Double In Utero Electroporation to Target Temporally and Spatially Separated Cell Populations

Published on: June 14, 2020

相关概念视频

Cleavage and Blastulation

Cleavage and Blastulation

After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.

In Vitro Fertilization

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...